Welcome to this week’s edition of The Guide ⚡️ 

Today’s newsletter takes about 5 minutes to read—so if you’ve only got 60 seconds, here’s what you need to know:

• Microdose gummies deliver sub‑perceptual doses of psychoactive compounds—usually psilocybin or lysergic acid diethylamide (LSD)—in a familiar, flavored format that simplifies titration.

• Evidence is still emerging. A 2024 rapid review of 19 placebo-controlled studies found measurable changes in mood, cognition, and neurobiology; however, the effect size is often modest, and expectancy plays a role.

• Legality varies widely. Oregon's licensed service‑center model and Colorado's Natural Medicine Act contrast with strict federal Schedule I status in the U.S.; Australia now allows psychiatrist‑prescribed psilocybin for PTSD and depression.

• Quality matters. Look for third‑party Certificates of Analysis (COAs) that confirm potency and screen for contaminants—now mandatory for licensed Oregon manufacturers.

• Risks include psychological distress and drug interactions. Case reports of serotonin toxicity in people taking SSRIs remind us that "micro" is not risk-free.

🤞 While we’re still waiting for legal changes to be made for increased accessibility, there’s still a lot of time to become educated about this quickly evolving sector within the plant medicine and psychedelic space.

Let’s dive into it…

🧠 The Webdelics Team

👋 New here? We do this every week… Join Us!

🎧️ The Webdelics Podcast

🎙️ In this week’s episode of The Webdelics Podcast, Scott Mason sits down with psychotherapist and integration specialist Ashley Booth to explore the foundations of safe, meaningful psychedelic work.

This conversation reframes micro/macro experiences as one part of a larger practice, highlighting why preparation, nervous-system regulation skills, and integration turn peak moments into lasting change over time…

🔓️ Ashley’s experiences and knowledge helped us unpack pivotal insights like:

• The limits of “insights alone” and why self-knowledge ≠ smooth sailing…

• Using practical frameworks like Internal Family Systems (IFS) and Kundalini yoga alongside plant medicine experiences…

• How to prepare for intense sessions (including 5-MeO-DMT), ride difficult waves, and reconnect with your inner self…

• The importance of building resilience through curiosity, consistency, and supportive communities…

❤️‍🩹 She also shares personal stories, from Burning Man to the therapy room, that helps users ground these tools in real life experiences.

📜 Top Article

🍬 Microdose Gummies - A 2025 Guide to Benefits, Risks, and Best Practices

🔈️ You’ve probably heard about people microdosing psychedelics to boost creativity or mood… It’s all over silicon valley and within the tech sector, being touted as a way to boost innovation, productivity, and expand one’s thinking.

But what does the science say about it? And where can you actually do it within legal jurisdictions?

Traditional macrodose approaches to improve mental health, addiction, mood, focus, and creativity can work for many, but not all…

And this is where microdose gummies are gaining interest.

🍬 What Are Microdose Gummies?

‍Microdosing means ingesting about 1⁄10 to 1⁄20 of a typical "full" psychedelic dose—enough to nudge perception and mood without overt hallucinations.

Microdose gummies package that dose in a shelf‑stable, chewable square (or bear) infused with either:

1. Psilocybin extract derived from Psilocybe cubensis mushrooms.

2. LSD analogs (e.g., 1P‑LSD) are often suspended in gelatin or pectin.

3. Functional mushroom blends that combine legal species (lion's mane, reishi) with sub‑perceptual psychedelics to target neuroplasticity.

Because each gummy is homogenized (when purchased in a legal and regulated environment), users can track outcomes with milligram-level consistency, providing an advantage over home-cut chocolate bars or raw capsules, which often vary in potency.

🔬 The Science Behind Microdosing

🧠 How Psychedelics Work at Low Doses

Both psilocybin (metabolized to psilocin) and LSD activate serotonin 2A (5‑HT2A) receptors, triggering downstream events that promote neuronal growth and network "desynchronization," a marker of heightened neuroplasticity.

fMRI work from 2024 showed that high doses of psilocybin dissolved the boundaries of the default-mode network for weeks after a single session, hinting at mechanisms that microdoses might tap more gently.

🧪 What the Latest Trials Say

• LSD & ADHD (2025, JAMA Psychiatry): Repeated 20 µg LSD doses were safe but did not outperform placebo on core ADHD symptoms, underscoring expectancy effects.

• Inter-individual Response (2024, Nature Translational Psychiatry): EEG and cognitive markers shifted most in participants with low baseline arousal, suggesting that the benefits of microdosing may depend on an individual's starting state of mind.

• Self‑Blinding Study (2021, eLife): Volunteers who randomized their capsules reported similar gains on placebo and active days, highlighting the power of mindset and context.

Collectively, controlled studies show subtle but reproducible neurophysiological changes, although clinical benefits (e.g., less rumination or improved concentration) remain mixed and often small.

✅ Crafting a Microdosing Protocol

We've listed out the most popular current microdosing protocols, along with their dose and suggested used, based on user experience and history with the specific plant medicines.

👉️ The Fadiman Protocol

• Schedule - 1 day on / 2 off

• Typical Dose: 0.1 g dried mushroom (≈ 4 mg psilocybin)

• Best For: Beginners; mood uplift

‍👉️ The Stamets “Stack” Protocol

• Schedule - 4 days on / 3 off

• Typical Dose: 0.05–0.2 g of dried mushroom + lion’s mane + niacin

• Best For: Cognitive & neurogenesis focus

‍👉️ “Every‑Other‑Day” Protocol

• Schedule - 1 on / 1 off

• Typical Dose: 5–10 µg LSD

• Best For: Productivity & flow

Pro Tip: Use a journal or app to log sleep, mood, focus, heart rate, and any side‑effects. Over 4–8 weeks you should see patterns (or lack thereof) that inform dose tweaks and whether or not you’re seeing benefits from the protocols.

⚠️ Risks & Who Should Avoid Microdosing

• Drug interactions: Especially SSRIs, MAOIs, and tramadol; Always consult your prescriber.

• Anxiety/dysphoria: Even tiny doses can surface difficult emotions, which is why psychedelic-assisted therapy is always suggested, even with microdosing.

• Psychosis risk: Avoid microdosing if you or close family members have a history of psychotic disorders like schizophrenia or bipolar disorder.

• Legal & workplace: Know local laws and employer policies (we provide this in the full article, which can be found HERE).

👀 As you can see, microdose gummies (in the right jurisdiction and purchased in a regulated, licensed environment) can be a great way to dip your toe into the world of plant medicine and psychedelics…

But it’s up to you to make sure you do it them in a safe, legal, and supported environment.

👉️ Subscribe to The Guide for evidence-based takes on psychedelics, research, and integration tools—delivered weekly to your inbox.

💬 The Journey Has Just Begun…

We believe we’re at an inflection point.

As psychedelics move from whispers to headlines, the space is crowded, but it’s early in it’s infancy with promise, hope, and opportunity.

🔎 At Webdelics, our compass is focused on clarity, communication, and community.

Our goal is to share evidence-based insights so you can ask sharper questions, make informed choices, and define what healing looks like for you…

🌱 Because this isn’t just about molecules, mechanisms, or what big pharma wants.

It’s about people, culture, and the practices that help us grow together.

🙏 Thanks for being here and for bringing curiosity, care, and discernment to the conversation.

Stay grounded, stay open, and take care of yourselves.

Until next time…

🧠 The Guide - by Webdelics

Disclaimer: Webdelics does not support or promote any illegal activities, including the use of substances that may be mentioned in this newsletter. We encourage all readers to familiarize themselves with and adhere to the laws in their region. Please note that Webdelics does not offer mental health, medical, or clinical services and should not be used as a replacement for professional medical, psychological, or psychiatric care, diagnosis, or treatment.