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Psychedelics and Chronic Pain

Chronic pain affects 1 in 5 adults in the US, and yet mainstream options—morphine, oxycodone, OTC medications, nerve blocks, etc.—only offer brief relief and a long tail of side‑effects…

Preliminary studies over the last few decades have hinted that classic psychedelics, paired with skilled psychological and mental health support, may rewire neurological pain circuits rather than simply mute them…

Here are some notable studies we think you should know about:

🧪 Cancer Pain - LSD Outperforms Opioids for Pain Relief

In a 1954 double‑blind trial, Drs. Eric Kast and Vincent Collins gave 50 terminal cancer patients hydromorphone, meperidine, then 100 µg of LSD.

The psychedelic provided deeper analgesia that lasted up to three weeks—long after the drug’s acute effects faded.

Patients also spoke more openly—and peacefully—about death…

⚡️ Cluster Headache - Breaking the “Suicide Headache”

A 2015 survey of 496 cluster headache sufferers found psilocybin or LSD ended attacks within 20 minutes and extended remission—something no standard drug achieves.

Over 70 % of the respondents reported meaningful protection, with another 40 % stating psychedelics prevented an attack cycle altogether…

🧠 Migraine - The First Placebo‑Controlled Trial

Yale neurologist Emmanuelle Schindler ran a crossover study where participants took placebo, then 0.143 mg/kg psilocybin two weeks later.

Interesting, the results showed that taking psilocybin resulted in 50 % fewer weekly migraine days, milder pain, and less disability, independent of how “trippy” the session felt…

🖐️ Phantom‑Limb Pain - A Case Report Breakthrough

In a unique study done in 2018 by the infamous neuroscientist V.S. Ramachandran, amputee Albert Lin tried psilocybin therapy plus mirror‑neuron visual feedback treatment, after a failed trial with pain medications.

With the combined treatment, his pain levels dropped by 50 % for three weeks, eventually entering remission—supporting underlying theories that psychedelics boost neuroplasticity and could help the brain “re‑map” the missing limb to improve sensory feedback.

By changing the brain and it’s internal connectivity, theories suggest that psychedelics may be able to restructure specific circuits responsible for sensing pain and discomfort…

🧫 Micro‑Dosing & Pain Tolerance

A 2020 Dutch study asked volunteers to dunk a hand in 3 °C (water.

Interestingly, a 20 µg micro‑dose of LSD increased pain tolerance by about 20 %—comparable to codeine—while lowering unpleasantness…

All without the hallucinations that come with a standard dose of LSD.

What Are The Latest Theories About How Psychedelics Work?

Researchers point to 5‑HT2A (serotonin) receptor–driven neuroplasticity, which can result in reduced inflammation, and a potential “reset” of brain networks promoting pain and neuroinflammation…

Unlike opioids, psychedelics have the potential to teach the nervous system a new, quieter baseline and change the brain, not just mask the symptoms.

It’s safe to say that the early evidence is promising, but not yet prescription‑ready.

Clinical trials are small and dosing, safety, and long‑term effects need rigorous testing…

But with more research comes more potential opportunities for finding answers to the chronic pain epidemic we’re currently facing…

🎉 Top Weekly Blog!

Our Top Psychedelic and Plant Medicine Blog from Webdelics

The Webdelics website has over 160+ evidence-based, research-backed blogs that were intentionally written to give you the facts, not just our opinions. 

📚️ Here is this week’s top blog on our site, rated by our readers:

• The Importance of Music During a Psychedelic Journey

🎶 Can the right playlist steer your mind toward breakthrough insights? 

This reader‑favorite post decodes the science of “sonic set & setting,” showing how rhythm and melody synchronize brain waves and guide emotion.

🧬 You’ll get therapist‑approved track‑list tips and volume guidelines so your next journey hits all the right notes.

💡 Curious why some songs spark awe while others derail the vibe? Find out here.

💬 We will leave you with this…

“The breeze at dawn has secrets to tell you. Don’t go back to sleep.” — Rumi

🌌 Every dawn is a doorway. Some open with silence, others with song, but each invites us to cross into fresh light.

🔭 Curiosity turns the key. However we inquire—through data, rhythm, or reverie—the act of looking again reshapes what we find.

🌀 Growth spirals, not lines. It pauses, circles back, then leaps—always bending toward more life.

Wherever today meets you—on the threshold, in the in‑between, or deep on the path—remember: The door is already ajar, and you carry the hinge.

Until next time…

🧠 The Guide - by Webdelics

Disclaimer: Webdelics does not support or promote any illegal activities, including the use of substances that may be mentioned in this newsletter. We encourage all readers to familiarize themselves with and adhere to the laws in their region. Please note that Webdelics does not offer mental health, medical, or clinical services and should not be used as a replacement for professional medical, psychological, or psychiatric care, diagnosis, or treatment.