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👉️ Microdosing. Lion’s Mane. Chaga. Reishi. Everyone has a take, but very few truly have the context.

This issue will give you the context, tools, and knowledge to let you decide what’s actually worth exploring…

Read on!

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🍄 In this episode, Scott Mason sits down with Jessica Depatie to explore a question that comes up everywhere from artist circles to Silicon Valley: can psychedelics actually support creativity? Together they unpack what “creativity” really is and it’s less about being an artist and more about learning to trust your perception, notice what matters, and bring something true to the surface.

🫶 They discuss how plant medicines like cannabis, psilocybin, and ayahuasca can temporarily quiet the inner critic, soften self-judgment, and create space for new perspectives to emerge. Jessica also shares why real creativity often requires courage by stepping outside rigid systems, loosening the need to “get it right,” and staying curious in the unknown.

🎧 Whether you’re trying to reconnect with your creative voice, looking for grounded ways to think about safe psychedelic use, or just craving a fresh lens on your day-to-day, this conversation offers practical insight and real inspiration for turning chaos into meaning.

Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental condition that affects focus, impulse control, and hyperactive behavior.

ADHD is most commonly diagnosed in children, though symptoms can persist into adulthood.

Individuals with ADHD often experience difficulties with concentration, impulsivity, and restlessness, and may face challenges in personal relationships, work, and school. It can also be associated with secondary conditions like anxiety and chronic stress.

ADHD is often categorized into three subtypes: inattention, hyperactivity, or a combination of both.

The condition is prevalent in about 7.6% of children and 5.6% of adolescents, and around 2.5% of adults continue to experience symptoms.

The most common ADHD treatments are stimulant medications, which include drugs like methylphenidate and amphetamines.

While effective for many, these medications can have side effects, such as appetite loss, anxiety, and difficulty sleeping.

For those who do not respond well to stimulants, non-stimulant medications like antidepressants are sometimes prescribed.

Non-pharmacological treatments, such as behavioral therapies, mindfulness, and biofeedback, offer alternative approaches.

Devices like the FDA-approved Monarch Trigeminal Nerve Stimulation (eTNS) have also been explored as non-invasive options, particularly for children who do not want to take medication.

As ADHD diagnoses have increased, concerns have grown about the overuse of stimulants.

This has prompted many to explore alternative treatment options, including the use of psilocybin mushrooms…

Psilocybin, the active compound in “magic mushrooms,” has shown promise for treating conditions like depression, anxiety, and addiction.

Researchers are now investigating its potential for ADHD, as it may help improve mental flexibility and brain function.

Microdosing psilocybin—taking sub-perceptual doses—has been associated with improvements in concentration, mood, and productivity.

A 2019 online questionnaire study showed that microdosing was a common self-treatment for ADHD, with many participants reporting better results than traditional medications.

In addition to psilocybin, non-psychoactive mushrooms like Lion’s Mane are also being studied for their cognitive benefits.

Lion’s Mane is known to promote nerve growth factor (NGF), a protein that supports brain health and could help individuals with ADHD improve attention and memory.

A 2022 naturalistic study on microdosing with psilocybin-containing mushrooms found significant improvements in ADHD symptoms.

Participants reported a reduction in symptoms, and those who microdosed without conventional medication had the most significant symptom relief.

Additionally, microdosing was linked to enhanced well-being, as measured by the WHO-5 Well-Being Index, further suggesting that it may not only help with ADHD but improve overall quality of life.

However, the study had limitations, including the lack of detailed information on dosages and preparation methods, which could affect outcomes.

Future research is needed to better understand how microdosing may work in combination with conventional treatments and explore its impact on other cognitive functions affected by ADHD, such as working memory and executive function.

Lion’s Mane, known for its cognitive-enhancing properties, is gaining attention for its potential role in treating ADHD. It stimulates the production of NGF, which is vital for neuron survival and synapse growth.

These effects could support attention, memory, and executive function, which are often impaired in ADHD.

Lion’s Mane also has anti-inflammatory properties, which could help address inflammation linked to ADHD.

Clinical studies on Lion’s Mane have shown promising results for cognitive health, with one 2009 study revealing significant improvements in participants with mild cognitive impairment.

While this study did not specifically focus on ADHD, it suggests Lion’s Mane may benefit cognitive health and could be valuable for ADHD treatment.

Beyond Lion’s Mane, other mushrooms like Chaga and Reishi are also being studied for their potential benefits in managing ADHD symptoms:

Research into the use of mushrooms for ADHD is still in its early stages, but both psilocybin and non-psychedelic varieties like Lion’s Mane show promising potential.

Psilocybin microdosing may provide an alternative to traditional treatments, offering symptom relief and enhanced well-being, but legal issues still surround its widespread use.

Meanwhile, Lion’s Mane’s cognitive benefits, combined with its anti-inflammatory properties, make it an exciting area of research for ADHD.

As studies continue, these natural options could become an essential part of holistic ADHD treatment strategies, offering an alternative for those seeking non-pharmaceutical approaches.

However, further research is needed to fully understand their effectiveness and how they can complement or replace conventional therapies…

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The more you know, the better decisions you can make…

And this week’s edition was all about understanding the known and unknown of this quickly changing landscape.

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